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Giant Magneto-resistance (GMR) has been used in various biomedical fields. Compared with traditional optical detection, GMR sensors have been proven to be more sensitive and suitable for the transducers of future integrated lab-on-chip systems. Magnetic particles (MPs) are widely used as tags for labeling biomaterials such as proteins, DNA/RNA and cells in bioassay. Superior to fluorescence probe, MPs do not dacay in the process of storage and detection, and a single MP can be detected and actuated by highly sensitive GMR sensors, as the advantage of stabilization and sensitivity.